Seroxat half life?

**Posts:** 35 · by **Louise McDermott** » Mon Oct 27, 2003 3:56 pm

Does anybody know what the half life of Seroxat is?

I read on another forum that it was 21 hours! Not so sure on that one, especially as they also said the half life of Prozac was 16-21 days, and I'm under the impression it's 8 days . . .

If anyone has any clues, it'd be much appreciated

Louise

**Posts:** 35 · by **Louise McDermott** » Mon Oct 27, 2003 4:17 pm

Well, what do you know? As soon as I posted I found this chart:

http://sl.schofield3.home.att.net/medic ... chart.html

Hope the link works

This seems to back up the claim of 21 hours . . .

Louise

**Posts:** 2821 · by **Roger Elliott** » Mon Oct 27, 2003 5:17 pm

Great find Louise!

For anyone who is wondering, the half-life of a drug is the time it takes to reduce to half the initial dose concentration in the bloodstream. That is, on average, how long the average metabolism takes to clear half the drug from the body.

This has serious implications for withdrawal, as a drug with a long half life (e.g. Prozac - half life 4-6 days) will smooth out troughs during withdrawal whereas a short half life drug (seroxat) will not.

The other important understanding is that long half life drugs build up in concentration significantly due to the long 'tail' in blood concentration.

This may well explain why many people have problems withdrawing from Seroxat and why Prozac is sometimes used as a 'buffer' to help anti-depressant withdrawal.

Roger

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